Fundamentals of Microbiology (12th Edition)

Name: Fundamentals of Microbiology

Edition: 12th

Author: Jeffrey C. Pommerville

Subject: Microbiology

Language: English

Publisher: Jones & Bartlett Learning

Fundamentals of Microbiology (12th Edition)

Brief Introduction

Fundamentals of Microbiology, Twelfth Edition provides that essential role and need. Besides the fundamental microbiological and disease aspects of COVID-19, which are discussed throughout the pages of this current edition, the textbook is an important tool for student learning in microbiology. It consolidates the important concepts and ideas necessary for mastery by students entering the health care field as a nurse or other allied health professional. Over many editions of Fundamentals of Microbiology, the textbook has reflected flexibility by evolving in response to the rapidly changing field of microbiology and the changing learning needs of students. I hope that you will find Fundamentals of Microbiology, Twelfth Edition welcoming and informative as you explore the amazing world of microbiology.


CHAPTER 1 Introduction to Microbiology: Then and Now

  • Microbial Communities Support and Affect All Life on Earth
  • The Human Body Has Its Own Microbiome
  • Microbiology Then: The Pioneers
  • The Microbial World Is Cataloged into Unique Groups
  • Microbiology Now: Challenges Remain

PART 1 Microbial Cell Biology
CHAPTER 2 The Chemical Building Blocks of Life

  • Organisms Are Composed of Atoms
  • Chemical Bonds Form Between Reactive Atoms
  • All Living Organisms Depend on Water
  • Living Organisms Are Composed of Four Types of Large Organic Molecules

CHAPTER 3 Naming, Observing, and Cataloging the Microbial World

  • Nomenclature Assigns a Scientific Name to Organisms
  • Microscopy Is Used to Visualize the Structure of Cells and Viruses
  • Staining and Other Light Microscopy Techniques Provide Contrast
  • Classifying Microorganisms Reveals Relationships Between Organisms

CHAPTER 4 Structure and Organization of Prokaryotic Cells

  • Prokaryotes Can Be Distinguished by Their Cell Shape and Arrangements
  • Bacterial and Archaeal Cells Have an Organized Structure
  • Cell-Surface Structures Interact with the Environment
  • Most Prokaryotic Cells Have a Cell Envelope
  • The Cell Cytoplasm Is Packed with Internal Structures
  • There Is Tremendous Diversity Among the Domains Bacteria and Archaea

CHAPTER 5 Eukaryotic Microbial Cells and Parasites

  • Eukaryotic Cells Contain a Variety of Organelles
  • The Eukaryotic Cell Arose from Prokaryotic Ancestors
  • The Fungi Include the Molds and Yeasts
  • The Protists Exhibit Great Structural and Functional Diversity
  • Parasitic Helminths Cause Substantial Morbidity Worldwide

CHAPTER 6 The Viruses and Other Infectious Agents

  • Filterable Infectious Agents Cause Disease
  • Viruses Have a Simple Structural Organization
  • Viruses Can Be Classified by Their Genome
  • Virus Replication Follows a Set of Common Steps
  • Viruses and Their Infections Can Be Detected in Various Ways
  • Some Viruses Are Associated with Human Tumors and Cancers
  • Emerging Viruses Arise from Genetic Recombination and Mutation
  • Prions Are Noncellular Infectious Agents

PART 2 Microbial Growth, Metabolism, and Genetics
CHAPTER 7 Microbial Growth and Nutrition

  • Microbial Growth and Reproduction Comprise the Cell Cycle
  • Optimal Growth Is Dependent on Several Physical and Chemical Factors
  • Culture Media Can Be Used to Grow Many Microbes
  • Population Measurements Are Made Using Pure Cultures

CHAPTER 8 Microbial Metabolism

  • Enzymes and Energy Drive Cellular Metabolism
  • Aerobic Respiration Is a Pathway to ATP Production
  • Anaerobic Metabolism Involves Other Pathways to ATP Production
  • Photosynthesis Converts Light Energy to Chemical Energy
  • Microbes Exhibit Metabolic Diversity

CHAPTER 9 Microbial Genetics

  • The Hereditary Molecule in All Organisms Is DNA
  • DNA Replication Is Part of the Cell Cycle
  • Gene Expression Produces RNA and Protein for Cell Function
  • Mutations Are Heritable Changes in a Cell’s DNA
  • Techniques Exist for Identifying Mutants

CHAPTER 10 Gene Transfer, Genetic Engineering, and Genomics

  • Bacterial Cells Can Recombine Genes in Several Ways
  • Genetic Engineering Involves the Deliberate Transfer of Genes Between Organisms
  • Microbial Genomics Studies Genes and Genomes at the Single-Cell to Community Levels

PART 3 The Control of Microorganisms

CHAPTER 11 Control of Microorganisms: Physical Methods and Chemical Agents

  • Microbial Growth Can Be Controlled in Several Ways
  • A Variety of Physical Methods Can Control Microbial Growth
  • Chemical Control Usually Involves Disinfection
  • A Variety of Chemical Agents Can Limit Microbial Growth

CHAPTER 12 Control of Microorganisms: Antimicrobial Drugs and Superbugs

  • Antimicrobial Agents Are Chemical Substances Used to Treat Infectious Disease
  • Synthetic Antibacterial Agents Primarily Inhibit DNA Synthesis and Cell Wall Formation
  • Beta-Lactam Antibiotics Target Bacterial Cell Wall Synthesis
  • Other Antibiotics Target Some Aspect of Metabolism
  • Several Tests Evaluate Microbial Susceptibility to Antimicrobials
  • Other Antimicrobial Drugs Target Viruses, Fungi, and Parasites
  • Antimicrobial Drug Resistance Is a Growing Challenge

PART 4 Microbial and Viral Diseases of Humans

CHAPTER 13 Diagnosing Infections

  • Several Methods Are Available to Identify and Diagnose an Infection
  • Clinical Specimens for Testing Must Be of High Quality
  • Phenotypic Methods Include Microscopy, Staining, and Biochemical Testing
  • Molecular Tests Make Use of Nucleic Acid Sequencing and Protein Detection
  • Serological Tests Involve Immunological Reactions

CHAPTER 14 Infectious Diseases of the Respiratory System

  • The Respiratory System and a Resident Microbiome Normally Hinder Bacterial Colonization
  • Several Microbial Infections Affect the URT
  • Some Pathogens Can Spread from the URT to the LRT
  • Several Other Prokaryotic, Viral, and Eukaryotic Pathogens Target the LRT

CHAPTER 15 Infectious Diseases of the Digestive System

  • The Digestive System Has a Diverse Resident Microbiome
  • Bacterial Diseases of the Oral Cavity Can Affect One’s Overall Health
  • GI Tract Pathogens Usually Are Spread Through Food and Water
  • Some Bacterial Diseases Are the Result of Foodborne Intoxications
  • GI Infections Can Be Caused by Several Bacterial Pathogens
  • Digestive System Illnesses Also Can Be Caused by Viruses and Eukaryotic Microbes

CHAPTER 16 Infectious Diseases Affecting the Skin, Soft Tissues, and Eyes

  • The Skin Contains a Resident Microbiome
  • A Variety of Skin Diseases Are the Result of Bacterial Pathogens
  • Several Viruses Are Associated with Human Skin Infections
  • Some Fungi and Parasites Can Invade the Skin
  • Several Infectious Diseases Affect the Eye

CHAPTER 17 Infectious Diseases of the Nervous System

  • The Nervous System Defenses Are Primarily Structural
  • Bacterial Diseases of the Central Nervous System Can Be Life-Threatening Emergencies
  • Some Viral Pathogens Target the Central Nervous System
  • Diseases of the Nervous System Can Be Caused by Eukaryotic Microorganisms

CHAPTER 18 Systemic Infectious Diseases

  • The Human Body Has Two Systems for Transporting Fluids
  • Several Circulatory System Diseases Are Caused by Bacteria and Helminthic Parasites
  • Systemic Bacterial Diseases Can be Spread by Arthropods
  • Viruses Can Cause Human Systemic Diseases
  • Malaria and Sleeping Sickness Are Two Prominent Systemic Protistan Diseases

CHAPTER 19 Infectious Diseases of the Urinary and Reproductive Systems

  • Urinary Tract Infections Are the Second Most Common Body Infection
  • Several Bacterial Species Are Associated with Urinary Tract Infections
  • Portions of the Female and Male Reproductive Systems Contain a Resident Microbiome
  • Several Prominent STIs Are Caused by Bacteria and Protists
  • Several STIs Are Caused by Viruses
  • The Human Immunodeficiency Virus (HIV) Is Responsible for HIV Infection and AIDS

PART 5 Interactions and Impact of Microorganisms with Humans

CHAPTER 20 The Host–Microbe Relationship and Infectious Disease Epidemiology

  • The Host and Microbe Have an Intimate Relationship in Health and Disease
  • Pathogens Differ in Their Ability to Cause Infectious Disease
  • Pathogens Are Transmitted from a Reservoir
  • Establishment of Infection Can Lead to Disease
  • Epidemiology Is Key to Fighting Infectious Diseases

CHAPTER 21 The Immune Response to Infection: Innate Immunity

  • The Immune System Is a Network of Cells and Molecules to Defend Against Foreign Substances
  • Surface Barriers Are the First Line of Defense
  • Innate Immunity Is a Cellular Response to Pathogen Invasion
  • Innate Immunity Also Produces Molecules That Affect or Damage Pathogens

CHAPTER 22 The Immune Response to Infection: Adaptive Immunity and Vaccination

  • The Adaptive Immune Response Targets a Specific Invading Pathogen
  • Humoral Immunity Is an Antibody-Mediated Immune Response to Infection
  • Cell-Mediated Immunity Is a T-Lymphocyte Response to Infection
  • Vaccines Can Build Adaptive Immunity to Some Infectious Diseases

CHAPTER 23 Infectious Disease and Immune Disorders

  • Type I Hypersensitivity Represents a Familiar Allergic Response
  • Other Types of Hypersensitivities Represent Immediate or Delayed Reactions
  • Autoimmune Disorders and Transplantation Are Immune Responses to “Self”
  • Immunodeficiency Disorders Can Be Inherited or Acquired

APPENDIX A Pronunciation Guide to Microorganisms
APPENDIX B Metric Measurement and Temperature Conversion Chart
APPENDIX C CDC Summary of Notifiable Diseases in the United States 2018



The Connecticut Department of Public Health (CDPH) has been notified of a cluster of possible foodborne illnesses, suggesting that there has been a foodborne outbreak. The public health officials quickly learn that the affected individuals all attended a catered lunch. Information about symptoms and foods eaten is gathered by interviewing attendees of the luncheon. Of the approximately 50 attendees, 30 (60%) are interviewed, and 19 (63%) interviewees reported symptoms include diarrhea, abdominal pain, and headache. The median interval from lunch to illness onset is 5.3 hours (range = 0.4–15.5 hours).


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